Fertility Square – The IVF Clinic

Preimplantation Genetic Diagnosis (PGD) or Preimplantation genetic screening(PGS)

Preimplantation Genetic Diagnosis (PGD) is an advanced technique used in IVF treatment. In this process embryos are analysed for any genetic abnormalities prior to embryo transfer and before they are implanted in the uterus. This procedure helps to eliminate embryos with chromosomal abnormalities or known genetic disorders and thus it increases the chances of conception after IVF treatment and the chances of having a healthy child. The method was initially developed as an alternative to prenatal diagnosis for couples who are at risk of passing on serious genetic diseases to their children. It thus avoids the need for the termination of pregnancy.
An increasing number of genetic disorders and chromosomal abnormalities can now be diagnosed by this technique.
The procedure involves doing an embryo biopsy on day 5 (at the blastocyst stage of the embryo). Usually 6-10 cells are removed from the outer layer of cells. The procedure needs high expertise and is carried out by trained embryologists. The biopsied cells are then analysed for any genetic abnormalities. Only the embryos found to be normal are used for embryo transfer later. The abnormal embryos are discarded.

PGD/ PGS is recommended for-

  • Couples who have a genetic disorder or are known carriers of genetic disease which can be transmitted to the child.
  • Couple who have a child with genetic disorder
  • Couples who wish to identify a tissue match for a sick sibling.
  • Advanced age of the female partner.
  • Recurrent implantation failures after IVF Treatment
  • Recurrent abortions

Adequate counselling is needed before PGD/PGS. There is possibility that none of the embryos may be detected as normal and so none will be available for transfer. Also, transferring a normal embryo doesn’t guarantee a successful IVF treatment as there are many other factors which can affect the IVF treatment outcome.